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At the urging of Arandjel, I decided to take a look at estrogen as an anti-aging skin care ingredient. I’m confining my research to topical estrogen and what its positive effects – if any – might be. For those interested in the broader topic of hormone replacement therapies, there’s a discussion thread led by Susan after my post on the Second Half of Your Life. Here I want to try to work out if the good imparted by topical estrogen outweighs the possible risks.

The general theory is that postmenopausal women on estrogen replacement therapy develop less wrinkles and have better skin texture and elasticity than those not taking estrogens. So, it seems logical that topical application of estrogen should also be helpful. There are two ways to do this. One is with a topical estradiol or estriol cream. The other is with phytoestrogens, plant-derived ingredients that mimic human estrogens.

Estradiol and estriol are typically used in gels to treat vaginal dryness in post menopausal women. As far as their success with dry, wrinkled skin is concerned there is one much-quoted study from the University of Vienna Medical School, Austria. The trial was conducted with 0.01% estradiol or 0.3% estriol on 59 postmenopausal women. After six months of treatment, a marked improvement in skin elasticity and firmness was noted; wrinkle depth and pore size decreased by over 60% in both estradiol and estriol groups. Skin moisture and collagen synthesis increased significantly.

However, other studies have not been so positive and in 2009, dermatologist Margaret E. Parsons, MD, FAAD from the University of California reviewed them and concluded that at best the results where mixed as to whether estrogen improves the appearance of the skin.

“Based on the research conducted thus far, it does not appear that topical or oral estrogens are a viable long-term solution for improving sun-damaged or aging skin,” said Dr. Parsons. “In my practice, I do not prescribe estrogens for skin rejuvenation because of the lack of consistent data to support their use and the known risks of prolonged estrogen therapy – including an increased risk of breast cancer.”

For example, one study examined whether low-dose hormone therapy improved aging skin in 485 women who were on average five years post-menopausal the study concluded that estrogen supplementation did not provide any significant improvement in sun-damaged skin.

Timing might be a factor as in one study, using Premarin cream, researchers observed a trend, although not statistically significant, of improvement in the skin of women who were less than 24 months postmenopausal. Two other studies concluded that the use of topical estrogens, such as Premarin cream or topical estradiol gel, could decrease fine wrinkling, improve roughness of the skin and stimulate collagen synthesis. Yet another found local that estriol, when applied to abdominal skin for three weeks, thickened fibers in the papillary dermis of patients.

Phytoestrogens are another option. They tend to appear in anti-aging creams as plant derivatives such as black cohosh or isoflavonoids derived from soy. It turns out that black cohosh may not even be a phytoestrogen. Soy isoflavones, on the other hand, are a class of estrogen-like compounds, specifically genistein and daidzein. There are a few studies that suggest that soy is promising.  In 2004, European researchers found that soy extract resulted in increased collagen and HA synthesis and “appears to rejuvenate the structure of mature skin”.

But some dermatologists are not convinced. Acne (of the post menopausal varieties) is one of the skin conditions that estrogen is supposed to help with. Decline of estrogen can leave testosterone unopposed and this can increase sebum activity leading to acne. However, Diane Thiboutot, M.D at Penn State Hershey College of Medicine the concentration of estrogen needed to decrease sebum production would need to be very high. If there were high doses of topical estrogens, they might be able to reduce sebum production and offset the effects of androgen and the development of acne, but there would be concerns about systemic side effects.”

How likely are those systemic effects? Dr Leslie Baumann cites a trial by Kainz et al on 17 women for three months with a topical that suggested no systemic effects and estrogen may, therefore, she concludes be useful for aging skin. Nonetheless, she urges extreme caution and treatment of a small area only by post-menopausal women.

Another part of the concern about estrogens in cosmetics is that they are there “by stealth” as ingredients that mimic human estrogen (albeit usually weakly), such as parabens and they have been controversially been linked to cancer. Some of these ingredients and the types of concerns are in my post Estrogen In My Shampoo and Copley’s Estrogen In My Face Cream.

The way I feel about topical estrogen is that there may be risk of cancer. Certainly more research is needed on this area. In the meantime, the evidence of benefits of topical estrogen hasn’t convinced me to take that risk with a hormone gel. Would that mean I would ditch a cream that had soy or black cohosh in it? No, not yet. When I looked at soy in some detail, it seemed to me that there wasn’t a very robust link to cancer in studies done so far and the amounts in cosmetic formulations are relatively small. On the other hand, they don’t really convince me as skin rejuvenators so I won’t be going out of my way to use them either.

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Known for its therapeutic property since generations, lemon helps to strengthen your immunity system and cleanses your stomach.

It is not only a blood purifier but also enables body to fight diseases. Lemon juice, especially, has several health benefits associated with it. Useful for treating kidney stones, curing heart strokes and reducing the body temperature, lemonade helps you to stay calm and cool.

Health benefits of lemon are due to many nourishing elements like vitamin C, vitamin B, phosphorous, proteins, and carbohydrates present in it. Lemon is a fruit that contains flavonoid, a composite that holds antioxidant and anti-cancer properties.

It helps to prevent diabetes, constipation, high blood pressure, fever, indigestion, provides skin , hair and dental care, and solves many other health problems.

Studies conducted at the American Urological Association highlight the fact that lemonade or lemon juice can cure kidney stones by forming urinary citrate, which can prevent formation of crystals.

People use lemon to make lemonade by mixing lemon juice with water. Many people use lemon as a washing agent, as it can remove stains.

Lemon can also repel mosquitoes.  Drinking of lemon juice with olive oil helps to get rid of gall stones. Lemon is well known for its medicinal control and is used in many different ways.

As per the results reported in a study of Annals of the Rheumatic Diseases, lemon provides human guard against inflammatory poly arthritis and arthritis.

Various health benefits of lemon can be described as under:

- Indigestion and Constipation:

Lemon juice helps to cure problems related to indigestion and consitpation. Add a few drops of lemon on your dish (take care lemon does not go well with milk), and it will aid in difestion.

Lemon acts as a blood purifier and a cleansing agent. A good drink post lunch or dinner is fresh lemon soda (also called fresh lime soda in many places). The recipe is add lemon juice, some cold water, soda, salts (common salt or rock salt) and sugar/honey (if you want it sweet), and mix it in a glass. You can also add some mint leaves or crushed fennel seeds for added taste. Drink this whenever you have a heavy lunch/dinner. 

- Fever:

Lemon juice can treat a person who is suffering from cold, flu or fever. It helps to break fever by increasing perspiration.

- Dental Care: Lemon juice is used in dental care also. If fresh lemon juice is applied on the areas of toothache, it can assist in getting rid of the pain. The massages of lemon juice on gums can stop gum bleeding.

It gives relief from bad smell and other problems related to gums. In addition, lemon can also be used in regular cleansing of your teeth.

You can look for a toothpaste containing lemon as one of the ingredients, or add a drop of lemon juice on your toothpaste.

Some people also rub their teeth with the outer shell (the inner side touching your teeth) of a lemon after removing the juice. Take care - if your mouth starts burning, quickly put some water in your mouth.

- Hair Care:

Lemon juice has proved itself in the treatment of hair care on a wide scale. Lemon juice if applied on the scalp can treat problems like dandruff, hair fall and other problems related to hair and scalp. Lemon juice if applied on the hair, gives a natural shine to hair.

- Skin Care:

Lemon juice, being a natural antiseptic medicine, can participate to cure problems related to skin.

Lemon juice can be applied to stop sun burn also. It helps to get relieved from bee sting as well. Lemon juice can also be applied on the skin for acne and eczema problems.

It acts as an anti ageing remedy and can remove wrinkles and blackheads. Drinking of lemon juice mixed with water and honey brings glow to the skin. If you search thoroughly in the market, you will find some soaps containing lemon juice also.

- Burns: Lemon juice if applied on the areas of burns can fade the scars. As lemon is a cooling agent, it reduces the burning sensation on the skin.

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Many moisturisers on the market contain large quantities of water to bulk them out and reduce the cost of the product. Water however dilutes the formulation, compromising its efficacy and leaving skin more vulnerable to the damaging effects of the elements.

Nothing dries out skin more than sun exposure - the primary cause of premature ageing. In order to keep skin hydrated, supple and young-looking, a rich moisturiser containing natural, active ingredients is an absolute necessity.

Aloe Super Hydrating Moisturiser is designed to bring the maximum benefit to skin whether it is mature and delicate or young and supple. Due to its high content of natural ingredients, it is even suitable for people with skin conditions such as psoriasis and eczema, and has a large following of people with these conditions.

Eternal Skincare's Aloe Super Hydrating Moisturiser took three to develop, and resulted in one of the finest and most effective moisturisers around. Free from parabens and other controversial preservatives, it contains high quantities of organically grown aloe leaf juice known for its cooling and calming properties which is especially effective on sunburnt skin.

Additional natural ingredients used for centuries to feed and nourish the skin complement the sublime blend, including the oils of rosehip, grapeseed, and sweet almond. Roman chamomile extract known to help promote skin cell regeneration and green tea extract which helps skin maintain its elasticity are also present in the exclusive formula.

The Moisturiser can be used on the delicate skin of the face and all over the body. Available in a large 225ml pot or a 12ml mini, it is a great way of experiencing a little luxury every day whether at home or abroad. Suitable for ladies, gentlemen and children.

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Clifton Park, NY (PRWEB) June 22, 2011

Strange as it sounds, the latest breakthrough in skin care might come from the bowels of earthworms. Known as Worm Castings, earthworm excrement is filled with peptides and enzymes that are clinically proven to repair damaged skin. Earthworm powder (made from dried worms), is already being used to extract cancer fighting enzymes for drug development. And organic farmers have been reporting relief from psoriasis and eczema after exposure to Worm Tea, a popular plant food made from worm castings and water. Now GSC Products has released the world’s first anti-aging cream using an exclusive extract made from earthworm castings.

Wrinkle Butter is part of the new Fresh Beauty Market brand, a line that also includes Cellulite Butter, Burn Butter, Pain Butter and DMAE Facial Cleanser. According to the manufacturer, their new Wrinkle Butter contains a higher concentration of anti-aging compounds than the most expensive creams and serums. Earthworm castings are rich in copper peptides, humates, auxins, kinetins and cytokinins that stimulate healthy cell growth, collagen production, firming of skin, hydration and uptake of nutrients - while fighting free radicals.

Organic farmers already know earthworm castings make plants grow larger and faster by promoting healthy stem cells and extending the life cycle with an arsenal of anti-aging enzymes. According to Wayne Perry, Head of Development for GSC Products, those same compounds produce similar anti-aging effects on human skin.

“After studying reports from organic farmers about the miraculous skin benefits of worm tea, we began developing a casting extract specifically for skin care and it really works. There’s no strange smell or anything like that. We make a proprietary earthworm extract that’s blended into a sterilized tincture. We add Green tea, Cayenne, MSM, Caffeine, Hyaluronic acid and Vegetable Glycerin. The final cream is blended with a natural organic base of Mango butter, Shea butter and Cocoa butter. It immediately makes skin firmer, softer and much more elastic. Customers have also reported relief from psoriasis and eczema symptoms as well,” says Perry.

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Oxygen is essential for a young-looking, radiant complexion, since it plays a role in the regeneration of new skin as well as in the production of collagen and elastin. The body’s ability to deliver oxygen to dermal tissue naturally declines over time, causing skin to look dull and to accumulate signs of aging like fine lines. It is believed that replenishing the skin’s oxygen at the cellular level will detoxify the epidermis from environmental pollutants internally and thus improve the appearance of skin externally. Cosmetic products and services touting this indispensable gas are marketed as a way to re-oxygenate the skin and restore its youthful glow.

Last week an esthetician tried to sell me on upgrading my facial with an oxygen treatment, but I declined based on the fact that Madonna is a big fan and, quite frankly, I’d rather not look like her. A blast of cooling oxygen sounds like a lovely way to finish off a facial and to achieve dewy skin, but it may in fact upset the skin’s physiological balance. As a Special Chem article explains, an excess of high-pressure oxygen applied to the skin’s surface can theoretically generate high levels of free radicals and degrade oxidizable molecules, such as some beneficial components of essential oils. Though oxygen treatments have been popular in spas and clinics for years, topical applications, which seem less marred by adverse side effects, are gaining steam.

Dermacyte is one of the latest brands to enter the cosmetic oxygen arena. Owned by Oxygen Biotherapeutics, Inc, Dermacyte’s two preliminary products, the Oxygen Concentrate and the Oxygenating Eye Complex, are formulated with a proprietary perfluorocarbon (PFC) oxygen carrier. Read more about PFC in this 2009 Cosmetics & Toiletries magazine article. Capable of transporting many times more oxygen than hemoglobin, this PFC was initially designed to enhance oxygen delivery to damaged tissues and speed up the healing process. After extensive research and aided by modern technology, the PFC was found to transfer large amounts of dissolved natural oxygen without the use of chemical activators like hydrogen peroxide, which has been associated with drying, bleaching, and damaging the skin. Its two introductory products aim to sequester atmospheric molecular oxygen and deliver it to the skin for cosmetic purposes.

It all sounded like high-tech mumbo-jumbo to me, but I figured maybe my skin could use a breath of fresh air. City life seemed to be taking a toll and my skin was looking particularly dull. Perhaps I needed more than organic botanicals and anti-aging peptides to bring back the fresh-faced glow that I hadn’t seen in months. It makes sense that skin cannot replenish the nutrients it needs without oxygen. Could Dermacyte’s oxygenating products be just the ticket to support my skin’s cell metabolism and restore radiance? Relegating my usual regimen to the back-burner, I simultaneously set out on testing the Oxygen Concentrate and Oxygenating Eye Complex, supplemented only with a daily moisturizer and sunscreen.

The Oxygen Concentrate disappointed right from the outset. Instead of breathing new life into my skin, I felt as if my skin was being suffocated under a worthless coating of chemicals. I expected slightly more for $84. Besides the patented perfluorocarbon, there is not much to the Oxygen Concentrate other than water, a surfactant, a polymer, a solvent, and a preservative. Yes, it’s a beautifully minimalist formula with the star active in the highest concentration.

But unless you fully subscribe to the theory that oxygen can be delivered topically to purify, replenish, moisturize, heal, and revitalize your skin, then all the Oxygen Concentrate does is essentially add a layer of synthetic fillers on your face. It is a rather uncomfortable layer at that, since the solution doesn’t seem to fully absorb and sits on the surface of the skin like a slick film. My microscopic .33 oz. container (the full-size version) lasted me less than two weeks. Granted, I used it as an all-over serum rather than a spot treatment, but in that time, I noticed no difference in my skin’s health. The Oxygen Concentrate neither brightened my complexion nor minimized wrinkles. It brought none of the miraculous benefits attributed to oxygen skin care, leading me to believe that, like other brands touting special oxygen delivery systems, this concept is full of hot air.

The Oxygenating Eye Complex is at the very least superior in terms of texture and formula. The lightweight, residue-free cream is absorbed readily as it moisturizes and subtly brightens. In addition, there is a large supply of back-up ingredients in case the glorified oxygen carrier doesn’t actually fulfill its destiny. Once you get past the synthetic skin-conditioning agents, you’ll find beneficial botanical emollients like shea butter, meadowfoam seed oil, sunflower oil, and avocado oil. There are also nourishing vitamins, like antioxidant-charged ascorbyl glucoside, a stable form of vitamin C combined with glucose, and niacinamide, a soluble form of vitamin B that maintains moisture levels in the skin.

The eye cream’s brightening effects might come from licorice root extract, an anti-inflammatory with skin-lightening properties, and from N-hydroxysuccinimide, an acidic ester that activates the elimination of pigments responsible for the dark color and inflammation which result in under-eye circles. A few of our favorite anti-agers even make an appearance, though closer to the bottom of the ingredients list. Palmitoyl oligopeptide and palmitoyl tetrapeptide-7 together make up Matrixyl 3000, which is believed to boost the growth of connective tissues and naturally increase the production of collagen. Unfortunately the good ingredients trail off toward the end, when controversial preservatives like chlorphenesin and phenoxyethanol take over.

Although I appreciated how my sleepy under-eye skin adapted to the Oxygenating Eye Complex, I was hardly blown away by a dramatically healthy-looking change. The cream certainly hydrated my skin and slightly improved its elasticity, but these effects were thanks to the formula’s emollients, antioxidants, and anti-inflammatories more than any dose of atmospheric oxygen. Another bonus over the restrained Oxygen Concentrate is that my half-ounce of eye cream (at $95, that’s $190 per ounce) lasted over the full trial of four weeks. However, I have experienced far better eye creams with a far smaller price tag and a far smaller collection of icky chemicals.

It took a team of scientists fifteen years to develop Oxygen Biotherapies Inc’s oxygen-based treatments for medical conditions and adapt them to cosmetic formulations. I’d be willing to bet that Demacyte’s products are priced so high to offset the costs incurred during those fifteen years of research and development. Three additional products are slated for launch later in 2011 to expand Dermacyte’s line. Based on the performance of its inaugural pair of products, my interest in oxygen delivery to skin has fully cooled off.

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